Serum antibody assay for determining protection from malaria, and pre-erythrocytic subunit vaccines

US10197577B2 · kind B2 · utility

Assignees

• Sanaria Inc. · US
• Antigen Discovery, Inc. · US
• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Philip Felgner · Rancho Santa Fe, US
• Stephen L. Hoffman · Gaithersburg, US
• Robert Seder · Chevy Chase Section Five, US
• Joseph J. CAMPO, JR. · Irvine, US

Key dates

• Filing date: Dec 29, 2017
• Grant date: Feb 5, 2019
• Expiry date: Dec 29, 2037

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are diagnostic methods and compositions for identifying individuals that are protected against Plasmodium falciparum caused malaria. Such methods are particularly useful for determining not only the protective efficacy of Pf whole parasite vaccines for individual subjects, but also within populations of vaccinated subjects. Also disclosed herein are subunit vaccines comprising at least one Pf immunologic determinant for protection against Plasmodium-caused malaria.