Heterocyclic compounds and methods of use thereof

US10202367B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• University of Kansas · US

Inventors

• Tsanyang Liang · Brookline, US
• Zongyi Hu · Potomac, US
• Juan Jose Marugan · Gaithersburg, US
• Noel Terrence Southall · Bethesda, US
• Shanshan He · North Bethesda, US
• Xin Hu · Chestertown, US
• Jingbo Xiao · Rockville, US
• Marc Ferrer · Potomac, US
• Wei Zheng · Rockville, US
• Kevin Frankowski · Lawrence, US
• Frank J. Schoenen · Lawrence, US
• Kelin Li · Lawrence, US

Key dates

• Filing date: Jun 12, 2015
• Grant date: Feb 12, 2019
• Expiry date: Jun 12, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of formula (I), formula (II), and formula (III): wherein Ar, R1, A, and X are as defined in the specification. These compounds are antiviral agents and are contemplated for use in the treatment of viral infections, for example, hepatitis C. These compounds are also contemplated for use in treating or preventing cancers.