Inhibitors of the renal outer medullary potassium channel

US10208064B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Alexander Pasternak · Brookline, US
• Ian Davies · Princeton, US
• Fa-Xiang Ding · Staten Island, US
• Jinlong Jiang · Scotch Plains, US
• Shuzhi Dong · Plainsboro, US
• Xin Gu · Scotch Plains, US
• Takao Suzuki · Shanghai, CN
• Joseph P. Vacca · Telford, US
• Zhifa Pu · Shanghai, CN
• Shouning Xu · Shanghai, CN

Key dates

• Filing date: Jul 9, 2015
• Grant date: Feb 19, 2019
• Expiry date: Jul 9, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.