Process for making chloro-substituted nucleoside phosphoramidate compounds

US10214554B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• John Y. L. Chung · Edison, US
• Amude Mahmoud Kassim · Fairless Hills, US
• John Limanto · Jersey City, US
• Michael Shevlin · Plainfield, US
• Peter E. Maligres · Fanwood, US
• Daniel A. DiRocco · Lebanon, US
• James F. Dropinski · Colts Neck Township, US
• Rose Mathew · Phoenixville, US
• Yi Ning Ji Chen · Clark, US
• Edward C. Sherer · Manville, US
• Mikhail Reibarkh · Cranford, US
• Artis Klapars · Scotch Plains, US
• Alan Hyde · Jersey City, US
• Susan L. Zultanski · Brooklyn, US
• Aaron J. Moment · Edison, US
• Bryon Simmons · Hillsborough Township, US
• Tyler Andrew DAVIS · Westfield, US
• Timothy Wright · Rahway, US
• Ralph Calabria · East Brunswick Township, US
• Louis-Charles Campeau · Morristown, US

Key dates

• Filing date: Feb 8, 2017
• Grant date: Feb 26, 2019
• Expiry date: May 21, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is directed to a process for making Chloro-Substituted Nucleoside Phosphoramidate Compounds of formula (I): which are useful for the treatment and prophylaxis of HCV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).