Hydroxyalkylamine- and hydroxycycloalkylamine-substituted diamine-arylsulfonamide compounds with selective activity in voltage-gated sodium channels

US10221167B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Thomas J. Greshock · Collegeville, US
• James Mulhearn · Cheltenham, US
• Junying Zheng · New Providence, US
• Ronald Kim · Essen, DE
• Ting Zhang · Princeton Junction, US
• Anthony J. Roecker · Harleysville, US
• Walter Won · Alpine, US
• Philippe G. Nantermet · Lansdale, US
• Rajan Anand · Wilmington, US
• Gang Zhou · Bound Brook, US
• Deping Wang · Furlong, US
• Liangqin Guo · Edison, US

Key dates

• Filing date: Dec 14, 2016
• Grant date: Mar 5, 2019
• Expiry date: Dec 14, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D285/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula A, or a salt thereof: wherein R1, R2, and E are defined herein, which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain disorders, cough, and itch using the same.