Process of preparing pharmaceutical compositions for the treatment of CFTR mediated diseases

US10231932B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Kelly Ann Swinney · Boston, US
• Patricia Hurter · Harvard, US
• David E. Nadig · Lansdale, US
• David Smith · Newton, US
• Vance Hayden Thomas · Duxbury, US
• Martin Paul Warman · Hingham, US

Key dates

• Filing date: Oct 31, 2014
• Grant date: Mar 19, 2019
• Expiry date: Apr 28, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/146
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Processes of preparing pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of administering, and kits thereof are disclosed.