Vitamin D receptor/SMAD genomic circuit gates fibrotic response

US10238667B2 · kind B2 · utility

Assignees

• Salk Institute for Biological Studies · US
• The University of Sydney · AU

Inventors

• Ning Ding · Beijing, CN
• Michael Downes · Village of La Jolla, US
• Christopher Liddle · Chatswood, AU
• Ronald M. Evans · Village of La Jolla, US
• Nanthakumar Subramaniam · Parramatta, AU

Key dates

• Filing date: Nov 8, 2017
• Grant date: Mar 26, 2019
• Expiry date: Nov 8, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/085
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis.