Peptide containing conjugates for dual molecular delivery of oligonucleotides

US10239957B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Steven L. Colletti · Princeton Junction, US
• Thomas J. Tucker · North Wales, US
• David M. Tellers · Lansdale, US
• Boyoung Kim · Lexington, US
• Rob Burke · San Diego, US
• Kathleen B. Calati · Hillsborough Township, US
• Matthew G. Stanton · Marlton, US
• Rubina G. Parmar · Cambridge, US
• Jeffery G. Aaronson · Philadelphia, US
• Weimin Wang · Hangzhou City, CN

Key dates

• Filing date: Nov 3, 2014
• Grant date: Mar 26, 2019
• Expiry date: Nov 3, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/3513
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein is a peptide containing conjugate comprising (P)c-(L)d-(G)e, wherein P is a peptide and each occurance of P is independently selected from Table 2; L is an optional linker and each occurance of L, if present, is independently selected from Table 3; G is a targeting ligand and each occurance of G is independently selected from Table 4; d is 0, 1, 2, 3, 4, 5 or 6; and each of c and e is independently 1, 2, 3, 4, 5 or 6. The conjugate can be administered to a subject either alone or in combination with a composition comprising R-(L)a-(G)b, wherein R is an oligonucleotide as defined herein, to inhibit expression of a gene of the subject.