Immunohistochemical proximity assay for PD-1 positive cells and PD-ligand positive cells in tumor tissue
US10241115B2 · kind B2 · utility
2Cited by
5References
18Claims
0Family size
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Key dates
| Filing date | Dec 8, 2014 |
| Grant date | Mar 26, 2019 |
| Priority date | — |
| Expiry date | Dec 8, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T2207/30204
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present disclosure describes an IHC assay for detecting and quantifying spatially proximal pairs of PD-1-expressing cells (PD-1+ cells) and PD-Ligand-expressing cells (PD-L+ cells) in tumor tissue, and the use of the assay to generate proximity biomarkers that are predictive of which cancer patients are most likely to benefit from treatment with a PD-1 antagonist. The disclosure also provides methods for testing tumor samples for the proximity biomarkers, as well as methods for treating subjects with a PD-1 antagonist based on the test results.
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