Patent · US Active

Synthesis of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10B-tetraaza-benzo[E]azulene and crytalline forms thereof

US10246460B2 · kind B2 · utility

1Cited by

0References

6Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Benno Rothenhaeusler · Soest, DE
Rene Trussardi · Basel, CH
Fabienne Hoffmann-Emery · Basel, CH
Urs Schwitter · Reinach, CH
Jean-Michel Adam · Rixheim, FR
Olaf Grassmann · Soest, DE
Thomas Hartung · Soest, DE
Frederic Ran · Kembs, FR
Ralph Diodone · Breisach am Rhein, DE
Christophe Pfleger · Mulhouse, FR
Bjorn Bartels · Schopfheim, DE

Key dates

Filing date	Jun 3, 2016
Grant date	Apr 2, 2019
Priority date	—
Expiry date	Jun 3, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/13
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.