Hypoxia-inducible factor 1 (HIF-1) inhibitors

US10246463B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Kirk R. Gustafson · Frederick, US
• Martin John Schnermann · Rockville, US
• Susanna T. S. Chan · Frederick, US
• Paresma R. Patel · Rockville, US
• William D. Figg · Fairfax, US
• James B. McMahon · Frederick, US

Key dates

• Filing date: Apr 6, 2016
• Grant date: Apr 2, 2019
• Expiry date: Apr 6, 2036

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of small molecule inhibitors of hypoxia inducible factor 1 (HIF-1) and pharmaceutical compositions thereof are disclosed. The disclosed compounds suppress HIF-1 activity by inhibiting the interaction between the HIF-1 α subunit and transcriptional co-activator protein p300. Embodiments of methods for making and using the small molecule inhibitors are also disclosed.