Newcastle disease viruses and uses thereof
US10251922B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 20, 2017 |
| Grant date | Apr 9, 2019 |
| Priority date | — |
| Expiry date | Oct 20, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/18143
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are chimeric Newcastle disease viruses engineered to express an agonist of a co-stimulatory signal of an immune cell and compositions comprising such viruses. Also described herein are chimeric Newcastle disease viruses engineered to express an antagonist of an inhibitory signal of an immune cell and compositions comprising such viruses. The chimeric Newcastle disease viruses and compositions are useful in the treatment of cancer. In addition, described herein are methods for treating cancer comprising administering Newcastle disease viruses in combination with an agonist of a co-stimulatory signal of an immune and/or an antagonist of an inhibitory signal of an immune cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.