Therapeutic compounds and uses thereof

US10258603B2 · kind B2 · utility

Assignees

• Genentech, Inc. · US
• Constellation Pharmaceuticals, Inc. · US

Inventors

• Brian K. Albrecht · Cambridge, US
• Steven Bellon · Wellesley, US
• Daniel J. Burdick · Burlingame, US
• Alexandre Cote · Cambridge, US
• Terry Crawford · San Mateo, US
• Les A. Dakin · Natick, US
• Vickie Hsiao-Wei Tsui · South San Francisco, US
• Michael Charles Hewitt · Somerville, US
• Yves LeBlanc · Toronto, CA
• Steven R. Magnuson · South San Francisco, US
• Christopher G. Nasveschuk · Stoneham, US
• F. Anthony Romero · South San Francisco, US
• Yong Tang · Cambridge, US
• Alexander M. Taylor · Cambridge, US
• Shumei Wang · Foster City, US

Key dates

• Filing date: May 10, 2017
• Grant date: Apr 16, 2019
• Expiry date: May 10, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, Rc, and Rd have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.