Labeled evans blue dye derivative for in vivo serum albumin labeling

US10258701B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Xiaoyuan Chen · Acton, US
• Lixin Lang · North Potomac, US
• Gang Niu · Shanxi, CN

Key dates

• Filing date: May 5, 2017
• Grant date: Apr 16, 2019
• Expiry date: May 5, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C09B45/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a compound of formula (I): wherein L, R1-R5, A, B, M, and n are as defined in the specification, as well as a method of preparing the compound. Also disclosed are a method of blood-pool imaging in a mammal and a method of imaging a lymph node in a mammal, comprising use of the compound.