Variants derived from ActRIIB and uses therefor
US10259861B2 · kind B2 · utility
17Cited by
76References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 1, 2016 |
| Grant date | Apr 16, 2019 |
| Priority date | — |
| Expiry date | Jul 1, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/70
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.