Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use

US10266565B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Terrence R. Burke, Jr. · Kirkwood, US
• Fa Liu · Watchung, US
• Kyung S. Lee · Gunpo-si, KR
• Jung-Eun Park · Suwon-si, KR

Key dates

• Filing date: Apr 12, 2012
• Grant date: Apr 23, 2019
• Expiry date: May 13, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.