Inhibitors of influenza viruses replication

US10273233B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Luc Farmer · Foxborough, US
• Michael Boyd · Winchester, US
• Dean Shannon · Milford, US
• Michael Waldo · Grafton, US
• Kwame Wiredu Nti-Addae · Tewksbury, US
• Yuegang Zhang · Wayland, US

Key dates

• Filing date: Nov 9, 2017
• Grant date: Apr 30, 2019
• Expiry date: Nov 9, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: include Hydrate 2 of Compound (1), Hydrate 3 of Compound (1), Form A of Compound (1), Form B of Compound (1), Form C of Compound (1), Form D of Compound (1), and amorphous Compound (1). Such polymorphic forms are useful for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.