Process for biosensor well formation

US10273536B2 · kind B2 · utility

Assignees

• Genia Technologies, Inc. · US
• Roche Molecular Systems, Inc. · US

Inventors

• Randall Davis · Pleasanton, US
• Edward Shian Liu · Saratoga, US
• Eric Takeshi Harada · San Jose, US
• Anne Aguirre · San Jose, US
• Andrew Trans · Bishop, US
• James Pollard · Bishop, US
• Cynthia Cech · Newcastle, US
• Hui Tian · Cupertino, US
• Robert Yuan · San Jose, US
• John Foster · Mountain View, US
• Roger Chen · Saratoga, US

Key dates

• Filing date: Mar 10, 2016
• Grant date: Apr 30, 2019
• Expiry date: Mar 10, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/48721
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A biochip for molecular detection and sensing is disclosed. The biochip includes a substrate. The biochip includes a plurality of discrete sites formed on the substrate having a density of greater than five hundred wells per square millimeter. Each discrete site includes sidewalls disposed on the substrate to form a well. Each discrete site includes an electrode disposed at the bottom of the well. In some embodiments, the wells are formed such that cross-talk between the wells is reduced. In some embodiments, the electrodes disposed at the bottom of the wells are organized into groups of electrodes, wherein each group of electrodes shares a common counter electrode. In some embodiments, the electrode disposed at the bottom of the well has a dedicated counter electrode. In some embodiments, surfaces of the sidewalls are silanized such that the surfaces facilitate the forming of a membrane in or adjacent to the well.