Roche Molecular Systems, Inc.
618Patents
536Active
618Granted
61Portfolio score
Filing activity: Nov 17, 1987 → May 15, 2024 · 109 expiring within 5 years
Most-cited patents
| Patent | Title | Area | Cited by | Status |
|---|---|---|---|---|
| US5994056A | Homogeneous methods for nucleic acid amplification and detection | Emerging Cross-Sectional Technologies | 597 | Expired |
| US5804375A | Reaction mixtures for detection of target nucleic acids | Emerging Cross-Sectional Technologies | 259 | Expired |
| US6171785A | Methods and devices for hemogeneous nucleic acid amplification and detector | Emerging Cross-Sectional Technologies | 234 | Expired |
| US6001611A | Modified nucleic acid amplification primers | Chemistry; Metallurgy | 233 | Expired |
| US5773258A | Nucleic acid amplification using a reversibly inactivated thermostable enzyme | Emerging Cross-Sectional Technologies | 192 | Expired |
| US7192745B2 | Method for the determination of a nucleic acid using a control | Chemistry; Metallurgy | 161 | Expired |
| US5677152A | Nucleic acid amplification using a reersibly inactivated thermostable enzyme | Emerging Cross-Sectional Technologies | 151 | Expired |
| US7666664B2 | Instrument for heating and cooling | Emerging Cross-Sectional Technologies | 114 | Active |
| US6127155A | Stabilized thermostable nucleic acid polymerase compositions containing non-ionic polymeric detergents | Emerging Cross-Sectional Technologies | 114 | Expired |
| US6399320B1 | Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction | Chemistry; Metallurgy | 101 | Expired |
| US5674738A | DNA encoding thermostable nucleic acid polymerase enzyme from thermus species Z05 | Chemistry; Metallurgy | 100 | Expired |
| US6040166A | Kits for amplifying and detecting nucleic acid sequences, including a probe | Emerging Cross-Sectional Technologies | 95 | Expired |
| US6214979A | Homogeneous assay system | Emerging Cross-Sectional Technologies | 79 | Expired |
| US6197563A | Kits for amplifying and detecting nucleic acid sequences | Chemistry; Metallurgy | 77 | Expired |
| US5789224A | Recombinant expression vectors and purification methods for thermus thermophilus DNA polymerase | Chemistry; Metallurgy | 69 | Expired |
| US5705627A | Detection of human papillomavirus by the polymerase chain reaction using specific L1, and E6 probes | Chemistry; Metallurgy | 68 | Expired |
| US7462709B2 | Method for the determination of a nucleic acid using a control | Chemistry; Metallurgy | 65 | Active |
| US5693517A | Reagents and methods for coupled high temperature reverse transcription and polymerase chain reactions | Emerging Cross-Sectional Technologies | 63 | Expired |
| US5939292A | Thermostable DNA polymerases having reduced discrimination against ribo-NTPs | Chemistry; Metallurgy | 61 | Expired |
| US6228628A | Mutant chimeric DNA polymerase | Chemistry; Metallurgy | 52 | Expired |
| US9005894B2 | Determination of KIR haplotypes associated with disease | Emerging Cross-Sectional Technologies | 52 | Active |
| US7378262B2 | Reversibly modified thermostable enzymes for DNA synthesis and amplification in vitro | Chemistry; Metallurgy | 50 | Expired |
| US6514736B1 | Kits for amplifying and detecting nucleic acid sequences | Emerging Cross-Sectional Technologies | 49 | Expired |
| US5639871A | Detection of human papillomavirus by the polymerase chain reaction | Chemistry; Metallurgy | 47 | Expired |
| US9347091B2 | Set of oligonucleotide probes as well as methods and uses thereto | Chemistry; Metallurgy | 45 | Active |
Source: USPTO / EPO open patent data. Counts and citation impact are objective bibliographic measures.