Epoxyazulene derivatives useful for treating cancer and diabetes

US10287297B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• FUNDACIÓ INSTITUT CAT ALÁ DINVESTIGACIÓ QUÍMICA (ICIQ) · ES
• Universitat Rovira I Virgili (URV) · ES

Inventors

• John A. Beutler · Braddock, US
• Antonio M. Echavarren · Tarragona, ES
• Laura Lopez · Barcelona, ES
• Fernando Bravo · Valls, ES
• Lorena Riesgo · El Berrón, ES
• Tanya Tannaquil Ransom · Germantown, US

Key dates

• Filing date: Apr 13, 2016
• Grant date: May 14, 2019
• Expiry date: Apr 13, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed is a compound of formula (I) in which R1-R5 and X1 are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer and a method of treating diabetes.