Anti-HIV domain antibodies and method of making and using same

US10287340B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Dimiter S. Dimitrov · Frederick, US
• Weizao Chen · Frederick, US

Key dates

• Filing date: Sep 28, 2015
• Grant date: May 14, 2019
• Expiry date: Oct 21, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/35
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides single domain antibodies and derivatives thereof that bind antigens of interest, which are stable, soluble, and do not tend to aggregate. The invention also provides methods for constructing a dAb library and methods for screening dAb libraries to identify the dAb of the invention. The invention also provide methods of treating or preventing conditions by antigen neutralization by administering the dAbs of the invention.