Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR[γ]

US10301272B2 · kind B2 · utility

Assignee

• PHENEX PHARMACEUTICALS AG · DE

Inventors

• Christian Gege · Ehingen (Donau), DE
• Christoph Steeneck · Dossenheim, DE
• Olaf Kinzel · Heidelberg, DE
• Gerald Kleymann · Bad Salzuflen, DE
• Thomas Hoffmann · Santa Cruz, US

Key dates

• Filing date: May 29, 2013
• Grant date: May 28, 2019
• Expiry date: Oct 27, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administering these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides carboxamide or sulfonamide containing cyclic compounds of Formula (1), (1′), (100), (100′), (200) and (200′) and the enantiomers, diastereomers, tautomers, /V-oxides, solvates and pharmaceutically acceptable salts thereof.