Therapeutic compounds and uses thereof

US10308614B2 · kind B2 · utility

Assignees

• Genentech, Inc. · US
• Constellation Pharmaceuticals, Inc. · US

Inventors

• Brian K. Albrecht · Cambridge, US
• Alexandre Cote · Cambridge, US
• Terry Crawford · San Mateo, US
• Martin Duplessis · Somerville, US
• Andrew C. Good · Wallingford, US
• Yves LeBlanc · Toronto, CA
• Steven R. Magnuson · South San Francisco, US
• Christopher G. Nasveschuk · Stoneham, US
• F. Anthony Romero · South San Francisco, US
• Yong Tang · Cambridge, US
• Alexander M. Taylor · Cambridge, US

Key dates

• Filing date: Aug 24, 2017
• Grant date: Jun 4, 2019
• Expiry date: Aug 24, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I): and salts thereof, wherein: R1-R4 have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of BRG1, BRM and/or PB1. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various BRG1-mediated disorders, BRM-mediated disorders and/or PB1-mediated disorders.