Process for making M1 receptor positive allosteric modulators
US10308633B2 · kind B2 · utility
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21Claims
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Key dates
| Filing date | Sep 26, 2016 |
| Grant date | Jun 4, 2019 |
| Priority date | — |
| Expiry date | Sep 26, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/28
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention provides novel processes for the preparation of compounds such as 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]benzo[h]-quinazolin-4(3H)-one, salts and derivatives thereof. The compounds synthesized by the processes of the invention are useful for treating Alzheimer's disease and other diseases (e.g., cognitive impairment, schizophrenia, pain disorders, and sleep disorders) mediated by the muscarinic M1 receptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.