Patent · US Active

Polymerase variants

US10308918B2 · kind B2 · utility

3Cited by

2References

9Claims

0Family size

Assignees

Roche Molecular Systems, Inc. · US
Genia Technologies, Inc. · US

Inventors

Aruna Ayer · Santa Clara, US
Arkadiusz Bibillo · Cupertino, US
Cleoma Arnold · San Jose, US
Charles Wayan Schwab · San Ramon, US
Eileen Thai · San Jose, US
Ilya Lederman · San Francisco, US
Colin Alexander McGaw · Santa Clara, US
Tyler O'Brien Shultz · Santa Clara, US
Barbara Eckert · Corona, US
Shawn Suko · El Sobrante, US
Mara Boenitz-Dulat · Tutzing, DE
Bigna Woersdoerfer · Munich, DE
David Daniel Wunderlich · Penzberg, DE

Key dates

Filing date	Feb 1, 2016
Grant date	Jun 4, 2019
Priority date	—
Expiry date	Mar 9, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y207/07007
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Described herein are variant pol6 polymerase having at least having at least two substitutions, wherein at least one of the substitutions is at position S366 of SEQ ID NO: 2. The disclosed polymerases may be coupled to alpha-hemolysin nanopores, and may be used in nanopore-based sequencing apparatuses.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.