Lutzomyia longipalpis polypeptides and methods of use

US10314900B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• FUNDAÇÃO OSWALDO CRUZ (FIOCRUZ) · BR

Inventors

• Jesus G. Valenzuela · Gaithersburg, US
• Jose M. C. Ribeiro · Rockville, US
• Aldina Barral · Tanque Novo, BR
• Manoel Barral Netto · Tanque Novo, BR
• Claudia I. Brodskyn · Tanque Novo, BR
• Regis Gomes · Tanque Novo, BR

Key dates

• Filing date: Jan 9, 2018
• Grant date: Jun 11, 2019
• Expiry date: Jan 9, 2038

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.