Therapeutic compounds and uses thereof

US10316023B2 · kind B2 · utility

Assignees

• Genentech, Inc. · US
• Constellation Pharmaceuticals, Inc. · US

Inventors

• Brian K. Albrecht · Cambridge, US
• Alexandre Cote · Cambridge, US
• Terry Crawford · San Mateo, US
• Martin Duplessis · Somerville, US
• Andrew C. Good · Wallingford, US
• Yves LeBlanc · Toronto, CA
• Steven R. Magnuson · South San Francisco, US
• Christopher G. Nasveschuk · Stoneham, US
• Richard Pastor · South San Francisco, US
• F. Anthony Romero · South San Francisco, US
• Alexander M. Taylor · Cambridge, US

Key dates

• Filing date: Mar 3, 2017
• Grant date: Jun 11, 2019
• Expiry date: Mar 3, 2037

Classification

• Technology area (CPC —): General

Abstract

The present invention relates to methods for treating PCAF mediated disorders using a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1, R3-R6, X, and each Re have any of the values defined in the specification. Also included are novel compounds of formula (I) and salts thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.