Patent · US Active

Anti-transferrin receptor antibodies with tailored affinity

US10323089B2 · kind B2 · utility

24Cited by

0References

9Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Stefan Dengl · Munich, DE
Guy Georges · Habach, DE
Ulrich Goepfert · Penzberg, DE
Jens Niewoehner · Munich, DE
Tilman Schlothauer

Key dates

Filing date	Dec 19, 2017
Grant date	Jun 18, 2019
Priority date	—
Expiry date	Dec 19, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/76
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Herein is reported an anti-transferrin receptor antibody that specifically binds to human transferrin receptor and cynomolgus transferrin receptor, which comprises i) a humanized heavy chain variable domain derived from the heavy chain variable domain of SEQ ID NO: 01, and ii) a humanized light chain variable domain derived from the light chain variable domain of SEQ ID NO: 26, wherein the antibody has an off-rate for the human transferrin receptor that is equal to or less than (i.e. at most) the off-rate of the anti-transferrin receptor antibody 128.1 for the cynomolgus transferrin receptor, whereby the off-rates are determined by surface plasmon resonance, and whereby the anti-transferrin receptor antibody 128.1 has a heavy chain variable domain of SEQ ID NO: 64 and a light chain variable domain of SEQ ID NO: 65.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.