Multispecific domain exchanged common variable light chain antibodies

US10323099B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Peter Bruenker · Hittnau, CH
• Christiane Neumann · Niederweningen, CH
• Christian Klein · Iffeldorf, DE
• Ekkehard Moessner · Kreuzlingen, CH
• Wolfgang Schaefer · Sankt Augustin, DE

Key dates

• Filing date: Apr 7, 2016
• Grant date: Jun 18, 2019
• Expiry date: Apr 7, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/73
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Multispecific antibodies based on antibodies that share a common light chain are described herein. The multispecific antibodies include: modified heavy chains having, by domain exchange, a common light chain variable domain VL; and two modified light chains having, by domain exchange, variable heavy chain domains of a first antibody (VH1) and a second antibody (VH2), wherein one light chain is of kappa isotype and one light chain is of lambda isotype. The present invention also relates to methods for the manufacture of such antibodies and their use.