Patent · US Active

CMV promoter and method for production of polypeptides

US10329595B2 · kind B2 · utility

0Cited by

0References

13Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Ulrich Goepfert · Penzberg, DE
Benjamin Moritz · Munich, DE

Key dates

Filing date	Nov 18, 2016
Grant date	Jun 25, 2019
Priority date	—
Expiry date	Nov 28, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2830/60
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The current invention reports a promoter that has the nucleic acid sequence of SEQ ID NO: 02 or SEQ ID NO: 03 which is a human CMV major immediate-early (hCMV-MIE) promoter/enhancer with C to G point mutation at position −41 and/or −179 relative to the transcription start site. This new promoter is especially useful for the production of polypeptides at large scale as it shows reduced promoter silencing and improved polypeptide production.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.