Method for increasing the specific production rate of eukaryotic cells
US10336983B2 · kind B2 · utility
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Key dates
| Filing date | Feb 9, 2017 |
| Grant date | Jul 2, 2019 |
| Priority date | — |
| Expiry date | Feb 9, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The current invention reports the use of meta-tyrosine for increasing the specific productivity of a eukaryotic cell that produces/expresses a polypeptide. In the current method it is not necessary to perform a temperature-, osmolality- or pH shift or to add drugs like valproic acid or sodium butyrate to modulate the specific productivity of the cultivated cells. The method does not affect cell viability or product titer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.