Anti-IL-1beta antibodies

US10344085B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Stefan Dengl · Munich, DE
• Peter Michael Huelsmann · Habach, DE
• Christian Gassner · Penzberg, DE
• Sebastian Breuer · Penzberg, DE
• Olaf Mundigl · Weilheim, DE
• Guy Georges · Habach, DE
• Ralf Schumacher · Penzberg, DE
• Guido Hartmann · Soest, DE
• Sabine Gruener · Weil am Rhein, DE

Key dates

• Filing date: May 9, 2017
• Grant date: Jul 9, 2019
• Expiry date: May 9, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Herein are reported humanized anti-IL-1beta antibodies that are humanized variants of the murine anti-IL-1beta antibody H34. A specific humanized antibody comprises (a) a HVR-H1 comprising the amino acid sequence of SEQ ID NO: 25, (b) a HVR-H2 comprising the amino acid sequence of SEQ ID NO: 27, and (c) a HVR-H3 comprising the amino acid sequence of SEQ ID NO: 28.