Thermostable respiratory synctial virus (RSV) vaccine compositions
US10369213B2 · kind B2 · utility
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Key dates
| Filing date | Oct 13, 2014 |
| Grant date | Aug 6, 2019 |
| Priority date | — |
| Expiry date | Dec 29, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/18551
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for improving the drying yield and stability of RSV vaccines comprising a highly thermolabile enveloped live virus and/or one or more RSV protein subunits, are described. Methods for rapid drying of RSV formulations containing between 17.5% and 60% w/w of a non-polymeric sugar and using either conduction or radiation dominant drying mechanisms, are disclosed. The disclosed methods provide for; 1) a dried RSV formulation with improved stability profile; 2) faster drying; and 3) integration of dried RSV into a primary device (such as dual chamber cartridges, foil-pouch devices etc.), pre- as well as post-drying.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.