Tricyclic gyrase inhibitors

US10385055B2 · kind B2 · utility

Assignees

• Merck Sharp & Dohme LLC · US
• Lawrence Livermore National Security, LLC · US

Inventors

• John Finn · Mercerville, US
• Leslie W. TARI · San Diego, US
• Zhiyong Chen · San Diego, US
• Junhu Zhang · San Diego, US
• Douglas Phillipson · Del Mar, US
• Suk Joong Lee · San Diego, US
• Michael Trzoss · San Diego, US
• Daniel Bensen · Carlsbad, US
• Xiaoming Li · Irvine, US
• Min Teng · Aliso Viejo, US
• Voon ONG · San Diego, US
• Allen Borchardt · San Diego, US
• Thanh To Lam · San Diego, US
• Felice C. Lightstone · Fremont, US
• Sergio E. Wong · Tracy, US
• Toan B. Nguyen · North Fair Oaks, US

Key dates

• Filing date: Sep 10, 2014
• Grant date: Aug 20, 2019
• Expiry date: Sep 10, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.