Patent · US Active

Process for preparing BTK inhibitors

US10385058B2 · kind B2 · utility

3Cited by

6References

54Claims

0Family size

Assignee

Genentech, Inc. · US

Inventors

Danial BEAUDRY · South San Francisco, US
Theresa CRAVILLION · South San Francisco, US
Francis Gosselin · South San Francisco, US
Ngiap-Kie Lim · South San Francisco, US
Sushant Malhotra · South San Francisco, US
Qingping Tian · San Diego, US
Haiming Zhang · Pennington, US
Alexander GMEHLING · Bad Säckingen, DE
Alec Fettes · Basel, CH
Stephan Bachmann · Allschwil, CH

Key dates

Filing date	Dec 14, 2017
Grant date	Aug 20, 2019
Priority date	—
Expiry date	Dec 14, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/09
WIPO fieldChemical engineering
WIPO sectorChemistry

Abstract

Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3′-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4′]bipyridinyl-2′-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided. Methods for preparing tricyclic lactam compounds are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.