Naphthyridines as inhibitors of HPK1
US10407424B2 · kind B2 · utility
3Cited by
0References
72Claims
0Family size
Assignee
Inventors
- Bryan Chan
- Naomi Rajapaksa
- Michael Siu
- Craig Stivala
- John Tellis
- Weiru Wang
- BinQing Wei
- Aihe Zhou
- Matthew W. Cartwright
- Emanuela Gancia
- Graham Elgin Jones
- Blake Daniels
- Michael Lainchbury
- Andrew Madin
- Eileen Mary Seward
- David Favor
- Kin Chiu Fong
- Andrew C. Good
- Yonghan Hu
- Baihua Hu
- Aijun Lu
- Joy Drobnick
- Lewis Gazzard
- Timothy Heffron
- Malcolm Huestis
- Jun Liang
- Sushant Malhotra
- Rohan Mendonca
Key dates
| Filing date | Mar 30, 2018 |
| Grant date | Sep 10, 2019 |
| Priority date | — |
| Expiry date | Mar 30, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D519/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.