Covalently linked helicar-anti-helicar antibody conjugates and uses thereof

US10407511B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Ulrich Brinkmann · Weilheim, DE
• Guy Georges · Habach, DE
• Eike Hoffmann · Viernheim, DE
• Georg Tiefenthaler · Sindelsdorf, DE
• Ekkehard Moessner · Kreuzlingen, CH
• Stefan Dengl · Munich, DE
• Achim Gaertner · Bad Heilbrunn, DE

Key dates

• Filing date: Jul 1, 2016
• Grant date: Sep 10, 2019
• Expiry date: Jul 1, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/75
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Herein is reported a conjugate comprising a helicar motif amino acid sequence containing compound and an antibody that specifically binds to the helicar motif amino acid sequence characterized by a covalent bond between the helicar motif amino acid sequence containing compound and an amino acid residue in the CDR2 of the anti-helicar antibody, whereby the CDR2 is determined according to Kabat.