Biocatalytic transamination process
US10407702B2 · kind B2 · utility
2Cited by
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11Claims
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Key dates
| Filing date | Aug 1, 2017 |
| Grant date | Sep 10, 2019 |
| Priority date | — |
| Expiry date | Aug 1, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y206/01
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A novel process is provided for the efficient preparation of an asymmetric compound of structural formula I: employing dynamic kinetic resolution (DKR). The DKR process involves an enzymatic enantioselective amination reaction catalyzed by transaminases. The process can be used to manufacture key intermediates in the preparation of poly (ADP-ribose) polymerase (PARP) inhibitors which may be useful for the treatment of cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.