Compositions and methods for the production of pyrimidine and pyridine compounds with BTK inhibitory activity

US10413562B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Brian L. Hodous · Cambridge, US
• Lesley Liu-Bujalski · Bedford, US
• Reinaldo Jones · Lowell, US
• Donald Bankston · Dracut, US
• Theresa L. Johnson · Salem, US
• Igor Mochalkin · Westford, US
• Ngan Nguyen · Arlington, US
• Hui Qiu · Lexington, US
• Andreas Goutopoulos · Boston, US
• Nadia Brugger · Cambridge, US

Key dates

• Filing date: May 3, 2018
• Grant date: Sep 17, 2019
• Expiry date: May 3, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F5/022
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides novel pyrimidine and pyridine compounds according to Formula (I), Formula (II), Formula (III), Formula (IV) and Formula (V) their manufacture and use for the treatment of hyperproliferative diseases including, but not limited to, cancer, lupus, allergic disorders, Sjogren's disease and rheumatoid arthritis. In preferred embodiments, the present invention describes irreversible kinase inhibitors including, but not limited to, inhibitors of Bruton's tyrosine kinase.