N1-phenylpropane-1,2-diamine compounds with selective activity in voltage-gated sodium channels

US10442778B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Anthony J. Roecker · Harleysville, US
• Mark E. Layton · Harleysville, US
• Thomas J. Greshock · Collegeville, US
• Joseph E. Pero · Harleysville, US
• Michael J. Kelly, III · Paoli, US
• Ting Zhang · Princeton Junction, US

Key dates

• Filing date: Mar 17, 2017
• Grant date: Oct 15, 2019
• Expiry date: Mar 17, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/0812
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula A-1, or a salt thereof: Formula A-1, where J, K, Q and R1 are as defined herein, which compounds have properties for inhibiting sodium ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-1 or their salts, and methods of treating pain (e.g. chronic pain), or cough or itch disorders using the same.