1-(chloromethyl)-2,3-dihydro-1H-benzo[E]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
US10442836B2 · kind B2 · utility
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34Claims
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Key dates
| Filing date | Jun 16, 2014 |
| Grant date | Oct 15, 2019 |
| Priority date | — |
| Expiry date | Jun 16, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.