Oligonucleotide compositions and methods thereof

US10450568B2 · kind B2 · utility

Assignee

• WAVE LIFE SCIENCES LTD. · SG

Inventors

• David Butler · Medford, US
• Sethumadhavan Divakaramenon · Lexington, US
• Christopher J. Francis · Arlington, US
• Maria Frank-Kamenetsky · Brookline, US
• Naoki Iwamoto · Watertown, US
• Genliang Lu · Winchester, US
• Subramanian Marappan · Acton, US
• Meena · Belmont, US
• Chandra Vargeese · Schwenksville, US
• Gregory L. Verdine · Boston, US
• Hailin Yang · Riverdale, US
• Jason Jingxin Zhang · Walpole, US

Key dates

• Filing date: Sep 23, 2018
• Grant date: Oct 22, 2019
• Expiry date: Sep 23, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/33
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.