L-2-hydroxyglutarate and stress induced metabolism
US10450596B2 · kind B2 · utility
2Cited by
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10Claims
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Key dates
| Filing date | Mar 27, 2015 |
| Grant date | Oct 22, 2019 |
| Priority date | — |
| Expiry date | May 3, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/7038
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides, among other things, methods and compositions for diagnosing and treating stress-induced injuries, hypoxia in particular. The present invention is based, in part, on the novel discovery that a metabolite, L-2-hydroxyglutarate, and certain enzymes and substrates regulating its metabolism, mediate stress-induced cellular mechanisms. In some embodiments, provided methods and compositions are used to diagnose and treat diseases with hypoxia-induced injuries. In some embodiments, provided methods and compositions are used to modulate cell pluripotency or differentiation in vivo or in vitro.
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