Tumor necrosis factor (TNF) family ligand trimer-containing antigen binding molecules

US10464981B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Maria Amann · Stintenberger Straße, CH
• Peter Bruenker · Hittnau, CH
• Christina Claus · Ennetbaden, CH
• Claudia Ferrara Koller · Schlieren, CH
• Sandra Grau-Richards · Schlieren, CH
• Christian Klein · Iffeldorf, DE
• Viktor Levitski · Schlieren, CH
• Ekkehard Moessner · Kreuzlingen, CH
• Pablo Umana · Wollerau, CH

Key dates

• Filing date: Mar 31, 2016
• Grant date: Nov 5, 2019
• Expiry date: Mar 31, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) a polypeptide comprising three ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by peptide linkers and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.