Methods for detecting expression of lnc-FANCI-2 in cervical cells

US10487365B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Zhi Zheng · Shenyang, CN
• Junfen Xu · Frederick, US
• Jun Zhu · Chandler, US
• Yanqin Yang · Bethesda, US
• Xiaohong Wang · Roy, US

Key dates

• Filing date: Sep 20, 2016
• Grant date: Nov 26, 2019
• Expiry date: Sep 20, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Described herein are biomarkers for HPV-associated pre-cancers and cancers such as cervical cancer and cervical intraepithelial neoplasia. The RNA binding protein (RBP) and long-noncoding RNA (lnc-RNA) biomarkers can be detected and used to diagnose HPV-associated pre-cancers and cancers. In addition, early diagnosis of HPV-associated pre-cancers and cancers can facilitate therapeutic intervention in patients, particularly in the pre-cancer stage which can delay or prevent progression to cancer.