Bicyclic BET bromodomain inhibitors and uses thereof

US10508106B2 · kind B2 · utility

Assignees

• ConverGene, LLC · US
• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Jeffrey Strovel · North Potomac, US
• Makoto Yoshioka · Gaithersburg, US
• David J. Maloney · Point of Rocks, US
• Shyh-Ming Yang · Doylestown, US
• Ajit Jadhav · Chantilly, US
• Daniel Jason Urban · Rockville, US

Key dates

• Filing date: Nov 23, 2016
• Grant date: Dec 17, 2019
• Expiry date: Nov 23, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders.