Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human Flt3L or GM-CSF for cancer immunotherapy

US10512662B2 · kind B2 · utility

Assignee

• Memorial Sloan Kettering Cancer Center · US

Inventors

• Liang Deng · New York, US
• Stewart Shuman · New York, US
• Jedd D. Wolchok · New York, US
• Taha Merghoub · New York, US
• Weiyi Wang · Hangzhou City, CN
• Peihong Dai · New York, US
• Ning-Sun Yang · Taipei, TW

Key dates

• Filing date: Feb 25, 2017
• Grant date: Dec 24, 2019
• Expiry date: Feb 25, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/24161
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates generally to the fields of oncology, virology and immunotherapy. More particularly, it concerns the use of poxviruses, specifically the replication competent attenuated vaccinia virus with deletion of thymidine kinase (VC-TK−) with and without the expression of human Flt3L or GM-CSF as oncolytic and immunotherapy. The foregoing poxviruses can also be used in combination with immune checkpoint blocking agents. The foregoing poxviruses can also be inactivated via Heat or UV-treatment and the inactivated virus can be used as immunotherapy either alone or in combination with immune checkpoint blocking agents.