Solid forms of (1S,4S)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide and methods of their use

US10513519B2 · kind B2 · utility

Assignee

• Signal Pharmaceuticals, LLC · US

Inventors

• Zheng Chen · Los Angeles, US
• Paul F. Fernandez · Roseland, US
• Tracy Lee Gaebele · Green Brook, US
• Lianfeng Huang · Jalan Pedongkelan, US
• Matthew Jackson · Warrington, GB
• Matthew Michael Kreilein · Fryeburg, US
• Xiaoling Lu · Whippany, US
• Wenju Wu · Hackettstown, US
• Jean Xu · Hackettstown, US

Key dates

• Filing date: Jul 5, 2018
• Grant date: Dec 24, 2019
• Expiry date: Jul 5, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are formulations, solid forms and methods of use relating to (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide.