Covalently linked antigen-antibody conjugates

US10517945B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Joerg Benz · Rheinfelden (Baden), DE
• Ulrich Brinkmann · Weilheim, DE
• Stefan Dengl · Munich, DE
• Sebastian Dziadek · Basel, CH
• Guy Georges · Habach, DE
• Michael Grote · Penzberg, DE
• Alexander Haas · Munich, DE
• Eike Hoffmann · Viernheim, DE

Key dates

• Filing date: Dec 19, 2014
• Grant date: Dec 31, 2019
• Expiry date: Feb 21, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof.