Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels

US10519147B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Thomas J. Greshock · Collegeville, US
• James Mulhearn · Cheltenham, US
• Liangqin Guo · Edison, US
• Ting Zhang · Princeton Junction, US
• Deping Wang · Furlong, US
• Ronald Kim · Essen, DE
• Mark E. Layton · Harleysville, US
• Michael J. Kelly, III · Paoli, US
• Rajan Anand · Wilmington, US
• Philippe G. Nantermet · Lansdale, US
• Tianying Jian · Westfield, US
• Anthony J. Roecker · Harleysville, US
• Walter Won · Alpine, US
• Gang Zhou · Bound Brook, US

Key dates

• Filing date: Dec 15, 2016
• Grant date: Dec 31, 2019
• Expiry date: Dec 15, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D285/135
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula A, or a salt thereof, where Q, X, R1 and R2 are as defined herein, which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain (acute, post-operative, neuropathic), or cough or itch disorders using the same.